Head and neck metachronous tumors - clinical, histopathological and immunohistochemical study

Vol. 60 No. 4, 2019

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Ion Cristian Mot, Marioara Poenaru, Carmen Aurelia Mogoanta, Anca-Maria Istrate-Ofiteru, Ioana Cristina Opriscan, Cristian Andrei Sarau, Marina Daniela Manescu, Viorela Enachescu, Carmen Adriana Dogaru, Cristina Popescu, Raluca Morar, Nicolae Constantin Balica, Ioana Delia Horhat

Multiple primary tumors (MPT) represent an important factor affecting the survival of some patients. They present an incidence of about 0.7-11% of all carcinomas developing in any region of the human body, being either synchronous or metachronous. These tumors raise problems of differential diagnosis, with tumoral relapses and distance metastases; also, they involve problems related to chemotherapy, radiotherapy and surgical treatment. In the present paper, we studied a group of 902 patients diagnosed with head and neck tumors admitted to the Ear, Nose and Throat (ENT) Clinic of the Emergency County Hospital of Timisoara, Romania, and we identified 12 patients with metachronous tumors, representing 1.33% of the hospitalized cases. Of the 12 patients with metachronous tumors, a single case was a woman, the other 11 cases being diagnosed in men. Regarding the age of the patients with metachronous tumors, only a single patient was aged less than 60 years old; most of them (nine patients) were aged between 60 and 69 years old, while two patients were aged over 70 years old. Nine patients were alcohol consumers, while 10 (83.33%) patients were smokers of about 20 cigarettes/day. All the metachronous tumors localized in the head and neck were squamous cell carcinomas. The second primary tumor was identified in the prostate, kidneys, ureter, lungs, salivary gland, thyroid gland, meninges, colon, rectum or skin.

Corresponding author: Carmen Aurelia Mogoanta, Lecturer, MD, PhD; e-mail: carmen_mogoanta@yahoo.com; Cristian Andrei Sarau, Lecturer, MD, PhD; e-mail: csarau@gmail.com

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