Histological and immunohistochemical study of cutaneous angiogenesis process in experimental third-degree skin burns treated with allograft
Vol. 53 No. 4, 2012
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Cristina Jana Busuioc, Florina Carmen Popescu, G. D. Mogosanu, H. Parvanescu, Liliana Streba, L. Mogoanta
Skin burns are a rather high incidence lesions which, depending on their depth and extension, can severely affect not only the skin but the entire organism. Third-degree skin burns extended on over 20% of the body surface often require skin graft. Skin allograft is a therapeutic alternative when autograft cannot be used. We investigated the allograft influence on the angiogenesis process in third-degree skin burns, using an experimental model. We noticed that the allograft induces a stronger inflammatory reaction associated with intense angiogenesis process by about 10-15% compared to control group.
Corresponding author: Laurentiu Mogoanta, Professor, MD, PhD; e-mail: laurentiu_mogoanta@yahoo.com
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