Histopathological aspects of benign epithelial tumors located in areas of friction or chronic irritation of the tongue

Vol. 52 No. 3 Suppl., 2011
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

A. Fronie, Daniela Dumitrescu, V. Vasca, Anca Simona Fronie

Besides lesions considered to be premalignant (such as erythroplasia, Bowen disease), a number of other potentially malignant lesions with higher or lower degree of epithelial dysplasia depending on the keratinization degree or determined by the action of carcinogens and irritants substances are described in the oral mucosa. Although they are practically considered the most harmless formations located on the oral mucosa, papillomas and condylomas are also the most frequent. In this study (conducted on a total of 38 cases with benign neoplasia) we planned a histopathological evaluation of surgical excision samples obtained from interventions on lingual neoplasias and harvested from the areas most exposed to chronic trauma or the areas in direct contact with mechanical irritants, in order to determine the histopathological pattern of the different types of histopathological lesions, the possible presence of keratosis-type changes or even possible dysplasias.

Corresponding author: Adrian Fronie, Lecturer, MD, PhD, e-mail: adrianfronie@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

B. Balinisteanu, Raluca Amalia Ceausu, Anca Maria Cimpean, Ionela Baciu, Nicoleta Baculescu, M. Coculescu, M. Raica

The large majority of neoplasms located in the sella turcica are benign pituitary adenomas derived from cells of the adenohypophysis. Pituitary adenomas represent the third most common primary intracranial tumor in neurosurgical practice, outnumbered only by gliomas and meningiomas. Their biology of pituitary adenomas is complex and they can cause a variety of endocrine syndromes and disorders, based on hormone profile secreted by proliferating cells. The aim of this study was to evaluate the routine conventional methods and highly specific immunohistochemical methods in order to accurately predict the type of hormone secretion. Our study was investigated 142 cases admitted with pituitary adenomas and treated by open surgery. Sections from each case were stained with routine Hematoxylin and Eosin method for histopathologic evaluation. Immunohistochemistry was performed on additional slides in order to detect specific pituitary adenomas. Based on the immunohistochemical profile of pituitary adenomas we found following results: 37 growth hormone (GH)-secreting adenomas, 23 prolactin (PRL)-secreting adenomas, 15 mixed GH-cell/PRL-cell adenomas, three mammosomatotroph cell adenomas, two adrenocorticotrophic hormone (ACTH)-secreting adenomas, one thyrotrophic cell adenoma, 18 gonadotroph adenomas, 30 null cell adenomas and 13 plurihormonal adenomas. No correlation was found between conventional features and the immunohistochemical profile. The immunohistochemical profile of functional pituitary adenomas is mandatory for a correct diagnosis. We revealed that staining characteristics of the tumor cells, such as acidophilic, basophilic or chromophobe are nowadays outdated as main principle of classification, because they not identify specific adenoma types.

Corresponding author: Anca Maria Cimpean, Associate Professor, MD, PhD, e-mail: ancacimpean1972@yahoo.com

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