Columnar cell variant of papillary thyroid carcinoma in an adolescent: a comprehensive histopathological, immunohistochemical, and molecular analysis

Vol. 66 No. 3, 2025

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Gizem Issin, Fatih Demir, Diren Vuslat Cagatay, Ismail Yilmaz

The columnar cell variant (CCV) of papillary thyroid carcinoma (PTC) is a rare histological subtype with distinct morphological and immunohistochemical (IHC) features, which can present diagnostic challenges. We report a case of a 13-year-old girl diagnosed with CCV of PTC (CCV-PTC) following a total thyroidectomy for a solitary thyroid nodule. Histopathological (HP) examination revealed aggressive features, including vascular invasion and extrathyroidal extension. However, no metastases or recurrences were observed during six years of follow-up. This case report provides a comprehensive analysis of a rare CCV-PTC in an adolescent, focusing on its HP, IHC, and molecular characteristics. It also discusses diagnostic pitfalls and differential diagnoses that should be considered.

Corresponding author: Gizem Issin, Associate Professor, MD, PhD; e-mail: gizemissin@gmail.com

DOI: 10.47162/RJME.66.3.17 Download PDF
Download cover
Download contents

Journal archive