Physical exercise and irisin: managing obesity and related comorbidities

Vol. 66 No. 2, 2025

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cristina Elena Negroiu, Robertina Iulia Tudorascu, Suzana Danoiu, Vlad Padureanu, Sanziana Godeanu, Raluca Danoiu, Adrian Ionut Ungureanu, Maria Cristina Bezna, Cristiana Gianina Moise

We live in an obesity pandemic characterized by sedentary lifestyles and unhealthy eating habits among more and more people. Therefore, it is crucial to understand the pathophysiology of obesity. A myokine secreted during exercise, irisin, has been the subject of many studies in recent years. It is well-known that physical exercise is one of the key therapeutic pillars in the fight against obesity. Irisin is a polypeptide hormone released during physical activity, and once it enters the bloodstream, it has numerous effects on the human body. This review aimed to highlight the latest studies on irisin, focusing on its structure, the mechanisms behind its release into the bloodstream, its effects on various organs, and, last but not least, how its serum levels change in different pathologies and its therapeutic effects.

Corresponding author: Robertina Iulia Tudorascu, Lecturer, MD, PhD; e-mail: irtudorascu@gmail.com; Cristina Elena Negroiu, Assistant Professor, MD, PhD; e-mail: cristina.negroiu@yahoo.ro

DOI: 10.47162/RJME.66.2.05 Download PDF
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