Morphological and clinical aspects of acute postmyocardial remodeling in patients with pre-existing hypertrophy

Vol. 66 No. 2, 2025

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Camelia Nicolae, Nicolae Paun, Madalina Andreea Munteanu, Cristina Florescu, Gabriela Uscoiu, Alice Elena Munteanu, Mihaela Paula Bolohan, Ioan Tiberiu Nanea

Introduction: Cardiac remodeling is a relevant and unfavorable evolution of myocardial infarction, which is associated with an increased risk of progression to overt heart failure (HF). It is currently acknowledged as a fundamental therapeutic objective that clinicians must address from the acute event to the comprehensive clinical follow-up. Aim: The aim of the study was to assess the importance of left ventricular hypertrophy (LVH) in acute myocardial infarction (AMI) extension. Patients, Materials and Methods: Inclusion criteria: anterior V1-V4 ST-segment elevation myocardial infarction (STEMI) and left ventricular ejection fraction (LVEF) >50%. Exclusion criteria: other STEMI locations, heart disorders, systemic diseases. Patients underwent pharmacological or percutaneous revascularization. Echocardiography was performed until day 3 of AMI and after 14 days. To measure the length of the expansion segment (LES), an original mathematical formula was obtained using the parasternal short-axis view at the papillary muscle level, myocardial mass (MM), and interventricular septum thickness (IST). Statistical studies have used the Student s t-test, the linear regression equations and the Pearson s correlation coefficient. Results: 172 AMI patients were analyzed and divided into two groups. Patients with LVH showed a strong reverse Pearson s correlation coefficient between LES and IST. For group II, a significant strongly reverse correlation for the LES and IST. Conclusions: Pre-existing LVH in AMI is associated with the limitation of the expansion. In the group without LVH, a 1 cm increase in LES corresponds to a 0.0622 cm decrease in IST.

Corresponding author: Madalina Andreea Munteanu, MD, PhD; e-mail: dr.amunteanu@gmail.com

DOI: 10.47162/RJME.66.2.12 Download PDF
Download cover
Download contents

Journal archive