The burden of cancer in metabolic dysfunction-associated steatotic liver disease

Vol. 65 No. 4, 2024

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Bianca Florentina Pirvu, Diana Clenciu, Luiza Andreea Beldie, Cristina Camelia Dica, Marilena Alexandra Burticala, Tiberiu Stefanita Tenea-Cojan, Adina Mitrea, Anca Maria Amzolini, Ion Cristian Efrem, Gabriel Florin Razvan Mogos, Ionela Mihaela Vladu

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and has become a major public health problem. MASLD frequently progresses to cirrhosis and hepatocellular carcinoma, but recent studies also show a frequent association with extrahepatic cancers. One of the mechanisms involved in both locations is insulin resistance and hyperinsulinemia. The aim of this narrative review was to present the main etiopathogenic mechanisms involved in cancer development in patients with MASLD.

Corresponding author: Tiberiu Stefanita Tenea-Cojan, Associate Professor, MD, PhD; e-mail: doctortts@yahoo.com; Adina Mitrea, Teaching Assistant, MD, PhD; e-mail: adina.mitrea@umfcv.ro

DOI: 10.47162/RJME.65.4.09 Download PDF
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