Adenocarcinoma of the ileum: literature insights on pyloric gland metaplasia

Vol. 65 No. 4, 2024

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Bogdan Stancu, Razvan Alexandru Ciocan, Marius George Teodorescu, Doinita Crisan, Florin Vasile Mihaileanu, Stefan Ursu, Liviu Tartacovschi, Stefan Lucian Popa, Claudia Diana Gherman, Octavian Aurel Andercou

Adenocarcinoma (ADK) of the ileum is an infrequent cancer that poses significant diagnostic and treatment difficulties. This article analyses the existing case literature to investigate the correlation between pyloric gland metaplasia (PGM) and the onset of ileal ADK. PGM, defined by the atypical transformation of intestinal epithelial cells into gastric-type mucosa, has been recognized as a possible precursor lesion in the spectrum of several gastrointestinal malignancies. We intend to clarify the clinical characteristics, histological results, and outcomes linked to ileal ADK originating from PGM through an exhaustive examination of recorded cases. Our findings indicate that early identification of metaplastic alterations may be essential for enhancing prognosis and informing therapeutic choices. This study emphasizes the need for additional research to elucidate the mechanisms driving this transition and to improve diagnostic precision in clinical practice.

Corresponding author: Razvan Alexandru Ciocan, Lecturer, MD, PhD; e-mail: razvan.ciocan@umfcluj.ro

DOI: 10.47162/RJME.65.4.05 Download PDF
Download cover
Download contents

Journal archive