Immunoexpression of E-cadherin, CD44 and Claudin 7 in gastric adenocarcinomas

Vol. 63 No. 3, 2022


Oana Iulia Cretu, Cristiana Eugenia Simionescu, Mirela Marinela Florescu, Mioara Desdemona Stepan, Konstantinos Sapalidis, Alex Emilian Stepan

Gastric adenocarcinomas represent frequent malignant tumors in the digestive tract, with a high and constant mortality rate in last decades. The disturbance of the adhesion molecules expression, which normally is essential in maintaining epithelial homeostasis, has a critical role in the initiation and progression of tumors. In this study, we analyzed the immunoexpression of E-cadherin, cluster of differentiation 44 (CD44), and Claudin 7 in 58 cases of gastric adenocarcinomas, in relation to the histopathological parameters of the lesions aggressiveness. Increased E-cadherin immunoexpression was observed in tubular adenocarcinomas, those of low grade and in stages I-III. CD44 presented high scores in discohesive, hepatoid, tubular, and tubulopapillary adenocarcinomas, those of high grade and in advanced stages. Claudin 7 associated increased scores for tubular, tubulopapillary and micropapillary tumors, those of low grade and mainly in stage I. The markers used in the study can be useful for assessing the aggressiveness of gastric adenocarcinomas, in the context of specific adapted therapy.

Corresponding author: Mirela Marinela Florescu, Teaching Assistant, MD, PhD; e-mail:; Mioara Desdemona Stepan, Lecturer, MD, PhD; e-mail:

DOI: 10.47162/RJME.63.3.07 Download PDF
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