Esophageal ulcer associated with mild hemophilia A: case report

Vol. 63 No. 3, 2022


Cristian Mircea Nicolescu, Alexandru Nesiu, Amelia Uzum, Damian Cristian Laza, Laura Corina Nicolescu, Paul Freiman, Andrei Ardelean, Razvan Ene, Teodora Daniela Marti

In this paper, we present the case of a 68-year-old male with personal medical history of coagulopathy issues, who presented to our Emergency Room (Emergency County Hospital, Arad, Romania) with bleeding of the superior tract of the digestive system; the case was difficult to manage, thus warranting the intervention of the Department of Gastroenterology. Endoscopy was performed to localize the site of bleeding and to stop the hemorrhage. This procedure was not successful. The patient was transferred to our Intensive Care Unit where different medications, such as proton pump inhibitor, hemostatic agent and prokinetic drugs were administered. Unfortunately, our attempt to stop bleeding failed; this led us to expand our investigation. We focused on a possible hemophilia as the cause of bleeding, which was confirmed as hemophilia A through the coagulometry test after a period of three days. Patient medical history and coagulation test led us to believe that this is a very rare case of a mild hemophilia A. Finally, the correction of Factor VIII deficiency and repeated endoscopic hemostasis clip was able to stop patients bleeding and ensured a favorable clinical evolution of the patient.

Corresponding author: Amelia Uzum, Lecturer, MD, PhD; e-mail:; Razvan Ene, MD, PhD; e-mail:

DOI: 10.47162/RJME.63.3.14 Download PDF
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