Role of ProEx C immunocytochemistry in cervical high-grade squamous intraepithelial lesions detection

Vol. 62 No. 4, 2021

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Carmen Ungureanu, Demetra Gabriela Socolov, Gabriela Anton, Eugenia Morosan, Laura Mihaela Trandafir, Ludmila Lozneanu, Mioara Florentina Trandafirescu, Elena Cojocaru

Background: Screening programs using Papanicolaou smear along with human papillomavirus (HPV) testing led to a significantly decrease of cervical cancer rates. Nevertheless, both assessments have limited specificity for revealing cervical high-grade lesions. The main problem is how to identify the real precursor of cervical squamous cell carcinomas (SCC), namely high-grade squamous intraepithelial lesions (HSIL). Aim: The aim of our study was to conclude if ProEx C might be used as a marker for high-grade cervical intraepithelial neoplasia (CIN). Materials and Methods: In this study, we detected the immunochemical expression of anti-ProEx C antibody in liquid-based cytology (LBC) samples. We analyzed a total number of 125 cervical cytology specimens. Results: In 48% of all cases, ProEx C was found to be positive. The percentage increased from 0% in negative for intraepithelial lesion or malignancy (NILM) cases to 100% in SCC cases. Conclusions: ProEx C may be utilized to improve the accuracy of cytological diagnosis on cervical smears, according to the findings of this study. This marker is also useful in detecting unrevealed high-grade lesions on atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesions (LSIL) smears, being very useful in establishing the conduct of these cases.

Corresponding author: Ludmila Lozneanu, Lecturer, MD, PhD; e-mail: ludmila.lozneanu@umfiasi.ro; Mioara Florentina Trandafirescu, Lecturer, MD, PhD; e-mail: mio.trandafirescu@umfiasi.ro

DOI: 10.47162/RJME.62.4.15 Download PDF
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