Intranodal palisaded myofibroblastoma expressing DOG1: focusing on the potential diagnostic pitfalls

Vol. 62 No. 3, 2021


Andreas Kontosis, Evripidis Valanikas, Theodosis Papavramidis, Triantafyllia Koletsa

Intranodal palisaded myofibroblastoma (IPM) is a rare, benign mesenchymal neoplasm of the lymph nodes with a broad differential diagnosis. We report a case of an 82-year-old woman presenting with a slow growing, right inguinal mass. The tumor arose as a circumscribed neoplasm inside a lymph node and consisted of bland spindle cells with nuclear palisading and intervening areas of amianthoid-like fibers among interstitial hemorrhage and hemosiderin-laden histiocytes in the stroma, typical histomorphological characteristics of IPM. Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin (SMA), beta-catenin, cyclin D1 and discovered on gastrointestinal stromal tumor (GIST) 1 (DOG1) immunostainings. A literature review and differential diagnosis of IPM are discussed. To the best of our knowledge, this is the first case of DOG1 immunoexpression in a case of IPM.

Corresponding author: Triantafyllia Koletsa, Associate Professor, MD, PhD; e-mail:

DOI: 10.47162/RJME.62.3.25 Download PDF
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