The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility

Vol. 62 No. 3, 2021


Simona-Daniela Neamtu, Liliana Stanca, Mirela Anisoara Siminel, Adela-Valeria Neamtu, Adrian Gluhovschi, Garofita-Olivia Mateescu, Anda-Lorena Dijmarescu, Maria-Sidonia Sandulescu, Anca-Maria Istrate-Ofiteru, Magdalena Rodica Traistaru

Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena.

Corresponding author: Liliana Stanca, Lecturer, MD, PhD; e-mail:; Mirela Anisoara Siminel, Lecturer, MD, PhD; e-mail:

DOI: 10.47162/RJME.62.3.21 Download PDF
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