Fortuitous discovery of melanomas in the ENT Department - a histopathological and immunohistochemical study

Vol. 61 No. 4, 2020


Cornelia Marina Trandafir, Alina Andreea Tischer, Ioana Delia Horhat, Nicolae Constantin Balica, Adrian Mihail Sitaru, Kristine Guran, Raluca Morar, Flavia Baderca, Emilia Manuela Jifcu, Ion Cristian Mot, Ovidiu Nicolae Burlacu, Marioara Poenaru, Cristian Andrei Sarau

The melanoma, having its origin in the melanocyte cells, is one of the most aggressive forms of skin cancer in the world with one of the highest rates of brain metastasis. The incidence of cutaneous melanoma in the Mediterranean countries varies from three to five cases/100 000 people/year. Its prognosis is based on an early diagnosis. Sinonasal mucosal melanoma (SNMM) is an extremely rare tumor, accounting for 0.3-2% of all melanomas. The non-specific symptomatology is often delaying the presentation of the patient at the hospital and therefore the diagnosis. The SNMM is a highly aggressive tumor, and the presence of metastasis at the diagnosis usually implies a poor prognosis. The management of the melanomas requires a precise pre-therapeutic assessment and a multidisciplinary approach for the diagnosis, with surgical treatment or radiotherapy required in order to ensure a better a quality of life. In this paper, we retrospectively analyzed two cases of mucosal melanoma and one case of cutaneous melanoma of the nose.

Corresponding author: Ovidiu Nicolae Burlacu, MD; e-mail:; Ion Cristian Mot, MD; e-mail:

DOI: 10.47162/RJME.61.4.18 Download PDF
Download cover
Download contents

Journal archive