Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

Vol. 61 No. 3, 2020

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Alina Costina Luca, Ingrith Crenguta Miron, Laura Mihaela Trandafir, Elena Cojocaru, Ioana Alexandra Paduret, Mioara Florentina Trandafirescu, Alin Constantin Iordache, Elena Tarca

Infantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might lead to local or systemic complications, depending on their morphological characteristics. The first line of treatment is beta-blockers, such as Propranolol, Timolol, Nadolol, administered either locally or systemically. Newer therapeutic strategies involving laser therapy and angiotensin-converting enzyme inhibitors are being studied, while older treatment modalities like corticosteroids, Imiquimod, Vincristine, Bleomycin and Interferon-alpha have become second line therapy options. Before establishing the appropriate treatment, clinical, histological, and imaging investigations are required.

Corresponding author: Elena Cojocaru, Associate Professor, MD, PhD; e-mail: ellacojocaru@yahoo.com; Laura Mihaela Trandafir, Associate Professor, MD, PhD; e-mail: trandafirlaura@yahoo.com

DOI: 10.47162/RJME.61.3.07 Download PDF
Download cover
Download contents

Journal archive