Clinico-imaging and morphological aspects of the benign serous ovarian epithelial tumors in children and adolescents

Vol. 60 No. 3, 2019


Mioara Desdemona Stepan, Cristina Adriana Becheanu, Alex Emilian Stepan, Cristiana Eugenia Simionescu, Mircea Ovidiu Ciobanu, Stefanita Bianca Vintilescu, George Alin Stoica, Elena Carmen Niculescu

Benign serous ovarian epithelial tumors represent a major area of interest in pediatric pathology through the incidence and the hormonal and reproductive implications that they induce. In this study, we analyzed 24 tumors diagnosed and surgically operated in children and adolescents, in relation to clinical, histological and immunohistochemical parameters, which can provide information on the potential for growth of lesions. The average age of diagnosis was 13.2 years, the majority of tumors being present in patients over 10 years (75%), with accompanying symptoms (83.3%), unilateral (91.7%) and dimensions of maximum 10 cm (66.7%). The histopathological aspect indicated a cystic growth pattern, sometimes papillary, and in three cases, the presence of atypical focal areas of the tumor epithelium. The Ki67 proliferation index values were higher in the case of tumors larger than 10 cm, those with papillary pattern, and in those with atypical areas, while p53 reactions were present only in cases with atypical proliferation areas. The parameters investigated in this study are useful both for assessing the risk of tumor growth and progression, as well as for stratifying patients for active clinical surveillance.

Corresponding author: Alex Emilian Stepan, Associate Professor, MD, PhD; e-mail:; George Alin Stoica, Lecturer, MD, PhD; e-mail:

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