An unusual onset of Crohn s disease with oral aphthosis, giant esophageal ulcers and serological markers of cytomegalovirus and herpes virus infection: a case report and review of the literature

Vol. 60 No. 2, 2019


Sergiu Marian Cazacu, Mirela-Corina Ghilusi, Elena Tatiana Ivan, Bogdan Silviu Ungureanu, Tudorel Ciurea, Adrian Saftoiu, Cristiana-Iulia Dumitrescu, Maria Fortofoiu, Ion Alexandru Vaduva, Carmen-Daniela Neagoe

Isolated esophageal ulcerations in Crohn s disease pose a great challenge in diagnosing and providing the correct treatment. We present the case of a 23-year-old woman with recurrent episodes of oral aphthosis, dysphagia, odynophagia and heartburn. Upper digestive endoscopy revealed an irregular mucosa with multiple ulcerations with irregular margins within the mid-esophagus. Immunoglobulin G (IgG) for cytomegalovirus and herpes virus were both positive. Four years after, she presented with the same symptoms and the involvement of ileo-colonic lesions, with pathological findings helped establish the Crohn s disease diagnosis. Crohn s disease represents an idiopathic chronic inflammatory gut disease, which can affect any part of the digestive tract. The onset by esophageal disease and no intestinal involvement is rare and challenging for a proper diagnosis.

Corresponding author: Bogdan Silviu Ungureanu, MD, PhD; e-mail:; Cristiana-Iulia Dumitrescu, Lecturer, MD, PhD; e-mail:

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