Histological findings from rat calvaria defect augmented with platelet-rich fibrin by using two consecutive periosteal incisions

Vol. 60 No. 1, 2019

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Alexandru Florian Grecu, Dragos George Popa, Cristian Virgil Lungulescu, Eduard Mihai Ciuca, Adrian Camen, Daniela Marinescu, Oliviu Nica, Cristina Jana Busuioc, Feng Ifrim Chen, Marius Eugen Ciurea

Background and Objectives: Platelet-rich fibrin (PRF) is a new generation of biomaterial that proved to be an effective tool in numerous clinical uses. This study aims at expanding the range effectiveness of PRF in promoting bone healing by histological evaluation. Materials and Methods: We performed a pair of two calvaria defects on 35 Wistar rats. The left defect was left empty as a control and the right defect was augmented with PRF. After 45 days, the experiment was terminated and the calvaria were collected and underwent morphological and histological analysis. Results: New bone formations have been shown to be prevalent in the PRF augmented defect. Conclusions: PRF increases the body s natural ability to heal and regenerate bone.

Corresponding author: Oliviu Nica, PhD Student; e-mail: oliviu.nica@gmail.com; Feng Ifrim Chen, Associate Professor, MD, PhD; e-mail: adsm.adsm@yahoo.com

Download PDF
Download cover
Download contents

Journal archive