Bisphosphonates-induced osteonecrosis of the jaw - epidemiological, clinical and histopathological aspects

Vol. 59 No. 3, 2018


Horatiu Cristian Manea, Horatiu Constantin Urechescu, Nicolae Constantin Balica, Marius Octavian Pricop, Flavia Baderca, Marioara Poenaru, Ioana Delia Horhat, Emilia Manuela Jifcu, Raluca Maria Closca, Cristian Andrei Sarau

Introduction: Osteonecrosis of the jaw (ONJ) is a multifactorial condition associated with bisphosphonates (BPs) treatment, head and neck irradiation, malignancy, chemotherapy, periodontal disease or trauma. The first cases of BPs-related ONJ (BRONJ) were reported over a decade ago. Patients, Materials and Methods: The study was retrospective and analyzed archived material. The study included 38 patients diagnosed and treated in the Clinic of Oral and Maxillofacial Surgery, Emergency City Hospital, Timisoara, Romania, for BRONJ, between 2013 and 2016. For all the cases were noted gender, age, localization of osteonecrosis, therapeutic indications for BPs (osteoporosis or malignancy), history of radiotherapy or chemotherapy, presence of bone metastases. If the treatment consisted in surgical removal of necrotic bone, the surgically removed specimens were sent to Service of Pathology of the same Hospital. The excised specimens were prepared with routine histological technique. Results: All the patients included in the current study were diagnosed with BRONJ. The patient history and clinical characteristics were the most useful diagnostic methods. Radiographic changes are not significant in early stages of osteonecrosis. The prevalence of BPs-associated ONJ is higher between 55-74 years old. Conclusions: ONJ is an important complication of BPs medication. The majority of affected patients develop this complication after dentoalveorar surgery, especially after dental extraction. Therefore, a good state of dental health is one of the most important directives when dealing with potential candidates for BPs therapy.

Corresponding author: Flavia Baderca, Associate Professor, MD, PhD; e-mail:; Marioara Poenaru, Professor, MD, PhD; e-mail:

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