The role of immunohistochemistry in the diagnosis and management of synovial sarcoma

Vol. 59 No. 2, 2018

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Daniel Laurentiu Pop, Roxana Folescu, Bogdan Nicolae Deleanu, Mihaela Iacob, Dinu Vermesan, Radu Prejbeanu, Daniel-Claudiu Malita, Horia George Haragus, Bogdan Catalin Ciupe, Carmen Lacramioara Zamfir, Gheorghe Noditi

Synovial sarcoma (SS) is a malignant soft tissue tumor representing 5-10% of all soft tissue sarcomas. Most synovial sarcomas are found at the extremities, especially in the lower limbs. A 28-year-old female presented at the Department of Plastic and Reconstructive Surgery, Dr. Pius Brinzeu Clinical Hospital, Timisoara, Romania, for evaluation of a mass located in the anterior region of the elbow. Imagistic, histological and immunohistochemically evaluations established the diagnosis of monophasic spindle cell SS G2. Block excision of the tumor with oncological safety margins was performed followed by total elbow arthroplasty. The patient then received radio- and chemotherapy. The case was followed-up at regular intervals for local recurrence and metastases and was free of symptoms at two years. Early diagnosis of SS, multimodal therapies and performing an arthroplasty of the elbow allowed the patient to resume daily activities. The unpredictable evolution requires regular follow-up for a long period of time.

Corresponding author: Roxana Folescu, Senior Lecturer, MD, PhD; e-mail: roxanafolescu08@gmail.com; Daniel-Claudiu Malita, Lecturer, MD, PhD; e-mail: d.malita@gmail.com

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