Cervical adenocarcinoma generator of procoagulant status and ischemic stroke

Vol. 58 No. 4, 2017

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Ana-Maria Bumbea, Magdalena-Rodica Traistaru, Stefan-Cristian Dinescu, Bogdan Stefan Bumbea, Dana-Maria Albulescu, Mihaela Niculescu, Boris Marinov Krastev, Anca-Emanuela Musetescu

The procoagulant status of neoplastic patients is well known in medical literature, but in the last years there is attempted a correlation between the histological types of neoplasia and the risk for thrombotic strokes. We present the case of a 44-years-old patient undergoing early menopause, who was diagnosed with cervical tumor of the serous adenocarcinoma type. The patient underwent external radiotherapy, and, in the seventh day of treatment, she suffered a frontal-temporal-parietal ischemic stroke with left hemiplegia. The blood testing highlighted procoagulant products (double fibrinogen compared to normal values, deficit of antithrombin and a high number of thrombocytes). The patient received neurological and rehabilitation treatment, at first with Heparin, followed by the administration of an antiaggregant. During this treatment, the deficit remained unchanged. She continued the neurological and rehabilitation treatment, followed by radiotherapy, with a good evolution. Six months after the stroke, it was decided the surgical tumor ablation of cytoreduction. The post-surgery histological examination highlighted specific changes due to post-surgery radiotherapy, without the presence of any neoplastic cells. The imagistic evaluation, computed tomography (CT) every three months after surgery, did not highlight any suggestive dissemination elements. The occurrence of an ischemic stroke in a patient with endocervical neoplasm of the adenocarcinoma type during radiotherapy imposed the discharge of chemotherapy, with subsequent imaging, biological and histopathological monitoring after surgery. The cause of stroke in this case is determined by the hypercoagulant status in the context of the developed neoplasia, the patient being free of any other risk factors.

Corresponding author: Magdalena-Rodica Traistaru, Associate Professor, MD, PhD; e-mail: rodicatraistru@hotmail.com

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