Fibrolamellar hepatocellular carcinoma with ovarian metastasis - an unusual presentation

Vol. 58 No. 1, 2017

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Silviu Horia Ciurea, Emil Matei, Codrut Silvian Stanescu, Ioana Gabriela Lupescu, Mirela Boros, Vlad Herlea, Niculina Ioana Luca, Bogdan Mihail Dorobantu

Aim: Fibrolamellar carcinoma (FLC) has been considered a distinct clinical entity vs. hepatocellular carcinoma, with respect to its epidemiology, etiology, and prognosis. Case presentation: We describe the unusual case of a 23-year-old female patient with FLC and ovarian (Krukenberg) and peritoneal metastases, clinically mimicking an ovarian carcinoma. Multiple recurrences occurred despite initial R0 resection and chemotherapy, requiring surgical treatment. The patient survived five years and died from generalized disease. Discussion: The particularities of our case are discussed by comparison with the other two similar cases and other date from the literature. Conclusions: To our knowledge, the ovarian involvement encountered in our case is the third case published in literature, being explained by the superficial location of the liver tumor.

Corresponding author: Emil Matei, MD; e-mail: emmatei@yahoo.com

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