Effect of Scutellariae herba extracts in experimental model of skin burns: histological and immunohistochemical assessment

Vol. 57 No. 4, 2016

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cornelia Bejenaru, George Dan Mogosanu, Ludovic Everard Bejenaru, Andrei Bita, Tudor-Adrian Balseanu, Floriana Elvira Ionica

The skin burns are an issue of great interest and seriousness in the public health domain, by their destructive features. Natural medicinal products are extensively used from ancient times, in ethnopharmacology, for the treatment of skin injuries (burns, wounds, ulcerations) due to the local modulation of the cellular response, in terms of emollient, demulcent, astringent, anti-inflammatory, antimicrobial, epithelizing, wound-healing, immunomodulatory and antioxidant effects. Aim: Histological and immunohistochemical assessment of antiseptic, anti-inflammatory, astringent and cicatrizing effects of Scutellariae (altissimae, galericulatae, hastifoliae) herba extracts administered in the form of 20% topical preparations (cold-creams), in experimental model of third degree skin burns, at Wistar rats. Caffeic acid and chlorogenic acid derivatives were identified in all herbal samples. The most active was the cold-cream with 20% Scutellariae hastifoliae herba soft extract, promoting the neoangiogenesis vessels and granulation tissue. Flavonoids, tannins and polyphenol carboxylic acids are the main active principles responsible for antiseptic, anti-inflammatory, astringent and cicatrizing effects of herbal extracts. Beeswax, from the formulation of cold-creams, acts as emollient, epithelizing, cicatrizing and biostimulator.

Corresponding author: Ludovic Everard Bejenaru, Lecturer, Biol, Pharm, PhD; e-mail: ludovic_bejenaru@yahoo.com

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