Immunolocalization of VEGF-A and orosomucoid-1 in odontogenic myxoma

Vol. 56 No. 2 Suppl., 2015
This supplement was not sponsored by Outside Organizations.


Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Hugo Dominguez-Malagon, Sirced Salazar-Rodriguez, Gabriel Tapia, Rogelio Gonzalez-Gonzalez, Nelly Molina-Frechero

Objective: The aim of the present study was to determine and establish the immunohistochemical distribution of VEGF-A and ORM-1 protein in odontogenic myxomas to suggest a possible function in the biological behavior of odontogenic myxomas. Materials and Methods: A total of 33 odontogenic myxoma cases and three tooth germs were included. Immunohistochemistry was performed to localize VEGF-A and ORM-1 proteins in tumor cells, endothelial cells and extracellular matrix in the odontogenic myxomas. The intratumoral microvessel density (MVD) was determined with CD34 and Factor VIII antibodies. Results: Immunopositivity was strong in the endothelial cells, which compose various vessels, and in the randomly oriented stellate, spindle-shaped and round tumoral cells with long cytoplasmic processes. More than half of the extracellular matrix lacked expression of VEGF-A. ORM-1 expression was strong in both endothelial cells and tumor cells, and the myxoid extracellular matrix was positive, with moderate or strong immunoexpression in all cases. An important finding of this study was the statistically significant positive correlation between the expression of ORM-1 and VEGF-A in tumor cells (p=0.02). Conclusions: The results of this study suggest that the expression of VEGF-A and ORM-1 may be associated with two mechanisms (angiogenesis and tumor structural viscosity) that may influence tumor growth in odontogenic myxoma.

Corresponding author: Ronell Bologna-Molina, DDS, PhD; e-mail:

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Ileana Peride, Ionel Alexandru Checherita, Diana Ruxandra Steluta Smarandache, Daniela Radulescu, Ruxandra Diana Sinescu, Andrei Niculae, Catalin Pricop

Vascular calcifications represent a severe complication of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) stage 5. The factors influencing the development of this complication are in close relation with the pathology of chronic dialysis premorbid condition, and with therapy as well. The present article highlights the association between several factors and the development or the aggravation of vascular calcifications in continuous ambulatory peritoneal dialysis (CAPD) patients. The results are not always in accordance with similar literature data, but there is a lack of researches regarding mineral metabolism in peritoneal dialysis patients versus those on chronic hemodialysis.

Corresponding author: Ionel Alexandru Checherita, Associate Professor, MD, PhD; e-mails:,

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