Medico-historical overview and histopathological comments about a hyalinizing trabecular tumor case of thyroid gland

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Cristian Barsu, Marina Barsu

Introduction: Hyalinizing Trabecular Tumor (HTT) of the thyroid gland is a rare and controversial tumor, whose rigorous identification is extremely important due to the difficulty of establishing a correct diagnosis using only the routine histological stains (Hematoxylin-Eosin, Periodic Acid-Schiff, van Gieson, etc.). Using only usual stains, difficult problems of differential diagnosis arise. In this paper, we report a clinically unexpected case of HTT, the first in Romania, whose diagnosis has been established only by immunohistochemistry reactions. Materials, Methods and Results: In assessing a case with nodular goiter for diagnose purpose, we have found a nodule difficult to diagnose. We have been determined to appeal to some additional immunohistochemical techniques. Conclusions: According to the immunohistochemistry reactions made, we found that particularly the Ki-67 immunohistochemical stain is obvious indispensable in establishing the diagnosis of HTT. We present also a medico-historical overview concerning some first descriptions of this rare entity. There are also mentioned some data regarding the behavior of this rare thyroid tumor.

Corresponding author: Cristian Barsu, Associate Professor, MD, PhD; e-mail:

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Carmen Corina Radu, Gabriela Mutiu, Ovidiu Pop

An accessory spleen (AS), or splenunculus, is a small nodule of splenic tissue found outside of the spleen. Post-mortem examinations, also known as autopsies, are carried out to identify a cause of death, and to assess the state of the organs of the deceased. We present two incidental cases of splenunculi, one localized in greater omentum and a second one localized in the hilum of the spleen, diagnosed during a histopathological examination. An immunohistochemical profile of the normal and accessory spleen was followed where the expression of the CD20, CD3, CD23, alpha-SMA were analyzed.

Corresponding author: Carmen Corina Radu, MD, PhD; e-mail:

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