Clinical and histopathological studies using fibrin-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Octavian Dinca, Sabina Zurac, Florica Staniceanu, Mihai Bogdan Bucur, Dana Cristina Bodnar, Cristian Vladan, Alexandru Bucur

The authors report their experience using platelet-rich fibrin (PRF) therapy for the treatment of ten patients presenting bisphosphonate-related osteonecrosis of the jaw (BRONJ). The aim of our study was to evaluate the effect of this therapy on recurrent BRONJ and to describe the clinical and histopathological/immunohistochemical staining features of PRF treatment. As such, we describe the method we used and report the results observed in the areas treated as well as side effects. The reported results recommend the safety and efficacy of PRF in treatment of BRONJ.

Corresponding author: Cristian Vladan, Teaching assistant, MD, DDS, PhD; e-mail:

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Anca Roxana Ungureanu, Dan Ionita, Liviu Draghici, Daniel Andrei, Dan Mircea Enescu, Isabela-Magdalena Draghici

The main role of the melanin production belongs to the keratinocyte-Langerhans-melanocyte complex that within a burn injury might be destroyed. A particular aspect has the pediatric patient with burns due to a deficit in pigment synthesis and particularities involving the growth process of facial structures. This article presents four eloquent cases of pediatric patients with sequelae, consequence of facial burns that varied in depth and etiology. The age of patients at time of admission was between four and 18 years, and the interval between production of the primary lesion and admission was variable (0-17 years). Conservative treatments prove to be insufficient, requiring the destroyed structures to be replaced with compatible tissue by surgical intervention. The therapeutic success of skin grafts and dermal substituents acknowledges the main role of plastic surgery. New technologies as well as new cell focused studies support the clinical proven results as well as they enlarge the spectrum of potential available therapeutic methods in order to obtain the best therapeutic results.

Corresponding author: Liviu Draghici, Assistant Professor, MD, PhD; e-mail:

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