Optical coherence tomography investigation of ischemic stroke inside a rodent model

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Eugen Osiac, Tudor-Adrian Balseanu, Laurentiu Mogoanta, Dan Ionut Gheonea, Ionica Pirici, Maria Iancau, Smaranda Ioana Mitran, Carmen Valeria Albu, Bogdan Catalin, Veronica Sfredel

Although already in use in several medical domains, only recently optical coherence tomography (OCT) has been applied in the study of ischemic events. In this paper, we will focus on characterizing ischemic stroke, in a rat model, by OCT. Investigations were carried on a set of 25 rats, on which ischemic stroke was inflicted by a transient occlusion of the middle cerebral artery (tMCAO). Animals were sacrificed 1, 3, 7 and 28 days after occlusion. We tested the OCT s power of detection and discrimination of stroke area compared to both normal, contralateral hemisphere and non-affected brain tissue, together with the aid of histochemical and pathological examination. Our results show a great potential of OCT to be used as a detection tool in acute and chronic phases of stroke.

Corresponding author: Bogdan Catalin, MD, PhD; e-mail: bogdan.catalin@webmail.umfcv.ro

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Sorina Maria Aurelian, Dan Mircea Cheta, Doina Onicescu

Microvesicles, also called microparticles or exosomes, are ultrastructural cellular components that have been widely researched in the past as well as present in order to establish their morphology, origin and role in physiological and pathological processes. Advanced techniques show that these microparticles have their clinical implications in the prevention and prediction in pathology and have potential in the discovery of novel therapeutic approaches to metabolic diseases such as diabetes, cardiovascular, autoimmune diseases and cancer.

Corresponding author: Sorina Maria Aurelian, MD; e-mail: sorinamaria.aurelian@gmail.com

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