The expression of CK19, vimentin and E-cadherin in differentiated thyroid carcinomas

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cristina Mariana Calangiu, Cristiana Eugenia Simionescu, Alex Emilian Stepan, Daniela Cernea, Roxana Eugenia Zavoi, Claudiu Margaritescu

Thyroid carcinomas constitute lesions with an ascending incidence, for which many prognosis assessment systems were developed. This study focused on analyzing the immunoexpression of CK19, vimentin and E-cadherin in a number of 43 differentiated thyroid carcinomas, of which 39 papillary carcinomas and four follicular carcinomas, and assessed the relationship of these markers with clinico-pathological parameters of interest, such as age and gender of patients, the histological type and subtype, tumor size and extension, metastases in regional lymph nodes and tumor stage. CK19 immunostaining indicated higher scores in conventional and follicular papillary carcinomas compared with tall cell variant. In relation to the size and extension of the tumor, we found significantly higher values of vimentin and E-cadherin scores in T1-T2 carcinomas compared with T3-T4 category and a positive linear distribution of these markers, which sustain their involvement in common mechanisms of tumor progression.

Corresponding author: Alex Emilian Stepan, Assistant, MD, PhD; e-mail: astepan76@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Maria Rotaru, Gabriela Mariana Iancu, Laura Gheuca Solovastru, Romanita-Firuta Glaja, Florin Grosu, Adriana Bold, Adrian Costache

Clear cell acanthoma, firstly described by Degos as an epidermal tumor with a particular aspect, although quite a rare lesion, raised an important interest because it may be easily confused with other dermatologic lesions, in the absence of a histopathological examination. Its clinical aspect is of a solitary nodule, with a red-brown varying color, with a size of 3 mm to 2 mm, sometimes covered with a thin scall. We present a case of a multiple rare cell acanthoma (seven nodular formations), having a rapid development (about two months) diagnosed in a 71-year-old patient within the lower 1/3 of the right shin.

Corresponding author: Laura Gheuca Solovastru, Associate Professor, MD, PhD; e-mail: lsolovastru13@yahoo.com

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