Inhibin alpha-subunit, Melan A and MNF116 in pheochromocytomas

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Diana Paun, Marius-Cristian Neamtu, Elena Taina Avramescu, Madalina Gabriela Georgescu, Rodica Petris, Dana Terzea, Catalina Poiana, Sorin Paun

Aim: The aim of this study was to make immunohistochemical analyses with Inhibin alpha-subunit, Melan A and MNF116 (pan-Cytokeratin antibody) in pheochromocytomas, because immunohistochemistry is useful for the distinction between adrenal tumors. Patients and Methods: We used 20 patients with pheochromocytomas submitted to laparoscopic (n=19) or classical (n=1) surgery and we have explored immuno-staining with Inhibin alpha-subunit, Melan A and MNF116 in these tumors. This can be helpful when we cannot make the distinction between adrenal tumors. Results: Pheochromocytomas did not stain with Inhibin alpha-subunit, Melan A and MNF116. Conclusions: In our study, Inhibin alpha-subunit, Melan A and MNF116 were not sensitive for pheochromocytomas._x000D_

Corresponding author: Madalina Gabriela Georgescu MD, PhD; e-mail:

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Ileana P. Marinescu, Maria Camelia Foarfa, Mihail-Cristian Pirlog, Adriana Turculeanu

Prenatal stress and depression affects 10-25% of pregnant women and is associated with disruption of fetal neurodevelopment, higher rates of placental abnormalities, preeclampsia, spontaneous abortion, or preterm birth. Markers of genetic vulnerability are catechol-O-methyltransferase, monoamine oxidase-A, variation of serotonin transporters, low levels of dopamine-beta-hydroxylase, and brain derived neurotrophic factor Val66Met (BDNF), while hyperactivity of HPA (hypothalamic-pituitary-adrenal) axis and massive release of endogenous cortisol, regulated by metalloproteinase-1, -2, -3 and -9, and are involved both in depressive symptoms and neurodevelopmental abnormalities in fetus. In women with prenatal stress and depression which suffered spontaneous abortion were observed placental abnormalities as regular shape and necrotic villi, decidua with large areas of necrosis, acute inflammation and effusion areas correlated with increase in proinflammatory factors, immune deficit and infections, hyaline type fibrosis, intervilos and deciduous intense hemorrhage, associated with increase of vascular endothelial growth factor. Taking into account the important societal and economic costs becomes important for an interdisciplinary approach, in which pregnancy and its risks are a central point for women mental health.

Corresponding author: Mihail-Cristian Pirlog, MPH, PhD; e-mail:

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