Microglia - performers of the 21st century

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Nidal Atallah, Renata Vasiu, Adina Bianca Bosca, Denisa-Ioana Cretu, Carmen Georgiu, Anne-Marie Constantin, Alina Simona Sovrea

At the frontier between immunology and neuroscience, microglia, the enigmatic macrophages of the brain, have generated, in recent years, increasing interest. In response to even minor pathological changes in the brain, these extremely versatile glial cells occasionally enter in an over-activating state and produce pro-inflammatory cytokines and free radicals, thereby contributing directly to neuroinflammation and various brain disorders. This review provides an analysis of the latest developments in the microglia field, considering the important new research that illustrate their involvement in brain related diseases.

Corresponding author: Renata Vasiu, Associate Professor, MD, PhD; e-mail: renata.vasiu@yahoo.com

Download PDF

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Roxana Chiorean, Michael Mahler, Cassian Sitaru

A wide range of skin diseases are associated with autoimmune responses against skin-specific or ubiquitous antigens. In many of these diseases, including autoimmune blistering disorders, collagenoses and vasculitides, extensive clinical and experimental evidence shows that autoreactive T-cells and/or autoantibodies play a major pathogenic role, allowing their classification as autoimmune diseases. The presence of tissue-bound and circulating autoantibodies does not only bear relevance for disease pathogenesis, but also allows developing robust diagnostic tools and molecular therapeutic approaches. Thus, various immunofluorescence methods, as well as molecular immunoassays, including enzyme-linked immunosorbent assay and immunoblotting, belong to the modern diagnostic algorithms for these disorders. This review article describes the immunopathological features of autoimmune skin diseases and the molecular assays currently available for their diagnosis and monitoring.

Corresponding author: Cassian Sitaru, MD, PhD; e-mail: cassian@mail.sitaru.eu, cassian.sitaru@uniklinik-freiburg.de

Download PDF