Effect of apitherapy products against carbon tetrachloride-induced toxicity in Wistar rats

Vol. 55 No. 3 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Calin Vasile Andritoiu, Vasile Andritoiu, Magdalena Cuciureanu, Delia Nica-Badea, Nela Bibire, Marcel Popa

The present paper aimed to evaluate the influence of apitherapy diet in Wistar rats with carbon tetrachloride induced hepatotoxicity, by the means of biochemical determinations and histopathological changes of liver, spleen, pancreas and testicular tissue. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution), 2 mL per 100 g, every two days, for two weeks. Hepatoprotection was achieved with two-apitherapy diet formulations (containing honey, pollen, propolis, Apilarnil, with/without royal jelly), that have been administered for six up to nine weeks. The biochemical results revealed that the two-apitherapy diet formulations had a positive effect improving the enzymatic, lipid, and protein profiles, coagulation, mineral parameters and also the bilirubin levels, after six weeks of treatment. The histopathological results demonstrated the benefit of the two-apitherapy diet formulations on reducing the toxicity of liver, spleen and pancreas in laboratory animals, after six and nine weeks, respectively. In conclusion, apitherapy products have a hepatoprotective effect in carbon tetrachloride-induced hepatopathy.

Corresponding author: Nela Bibire, Associate Professor, PhD; e-mail: nelabibire@yahoo.com

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Mihail Dan Cobzeanu, Vasilica Baldea, Mircea Catalin Baldea, Patricia Sonia Vonica, Bogdan Mihail Cobzeanu

Introduction: One of the aspects that have an influence on rhinosinusal endoscopic surgery is extrasinusal pneumatization, which can also affect less common structures at this level. The pneumatization of the superior and supreme turbinates, uncinate process and crista galli are perfect examples of this situation. The diagnosis is made only through imaging methods. Materials and Methods: This is a retrospective anatomo-radiological study analyzing 205 CT scans of the facial sinuses performed over a three years period. All patients were symptomatic and the CT scans were performed to assess the cases prior to surgery. Ninety-seven patients were females and 108 males, aged between 18 and 91 years. Results: The prevalence of pneumatization and the prevalence of the different pneumatization types (superior and supreme turbinate, uncinate process and crista galli) were determined. Conclusions: The pneumatization of the supreme turbinate (10.24%) was less common than that of the superior turbinate (29.76%) and affected all its anatomical variations (A, B, C). Pneumatization of the crista galli process was recorded in 22.92% of the cases, especially in association with type 2, while the prevalence of pneumatized uncinate process was of only 3.41% (uni- or bilateral).

Corresponding author: Mihail Dan Cobzeanu, Professor, MD, PhD; e-mail: cobzeanu_dan@yahoo.com

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