Multiple disseminated glomuvenous malformations: do we know enough?

Vol. 53 No. 4, 2012

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

C. Solovan, Elena Chiticariu, Doina Beinsan, Sabina Zurac, Flavia Baderca

Multiple glomuvenous malformations (GVMs), also known as glomangiomas, are uncommon entities with histological features of both glomus cells proliferation and venous malformation. A 14-year-old boy was admitted to our clinic with multiple dermal blue nodules, disseminated in different segments of the body. The patient's family history was positive for similar lesions; his mother and maternal grandmother had some asymptomatic blue nodules on their body. Histological examination showed a tumor composed of multiple caveronous vessels surrounded by glomus cells, positive for alpha smooth muscle actin, HHF35 (pan-actin), and h-caldesmon. This is a case of multiple GVMs, a rare disease caused by mutations in glomulin gene, with an autosomal dominant pattern of inheritance. The clinical and histopathological features are briefly discussed.

Corresponding author: Flavia Baderca, Assistant Professor, MD, PhD; e-mail: flaviabaderca@yahoo.com

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