The immunoexpression of EGFR and Her2/neu in oral squamous carcinoma

Vol. 53 No. 3 Suppl., 2012
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

L. P. Dragomir, Cl. Margaritescu, Alma Florescu, A. D. Olimid, Manuela Dragomir, M. R. Popescu

In this study, we have analyzed the EGFR and Her2/neu expression in oral squamous carcinoma and adjacent dysplastic areas. The lesions were diagnosed especially in the sixth decade of life, in male patients, localized on the lips, especially as well and poorly differentiated carcinomas (34%). The EGFR immunostain has been intense in over 50% of the tumors cells in well-differentiated carcinomas, expression diminished in the moderately and poorly differentiated carcinomas. Her2/neu marker recorded a score of 3+ in moderately and poorly differentiated carcinomas, the reaction turning out positive in 25% of the cases.

Corresponding author: Claudiu Margaritescu, Associate Professor, MD, PhD; e-mail: c_margaritescu2000@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Irina Anca Eremia, Maria Ciobanu, T. Tenea, Maria Victoria Comanescu, Stefania Craitoiu

Papillary lesions of the breast, both being and malignant, can prove to be a very challenging diagnosis in histological preparations. This study emphasizes on the importance of immunohistochemistry and in particular, the identification of myoepithelial cells for the correct evaluation of these lesions.

Corresponding author: Irina Anca Eremia, MD, PhD student; e-mail: irinaeremia@yahoo.com

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