VEGF and CD105 immunoexpression in squamous cervical carcinomas and associated precancerous lesions

Vol. 53 No. 3 Suppl., 2012
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Desdemona Stepan, Cristiana Simionescu, A. Stepan, Mihaela Muntean, B. Voinea

In this study, we analyzed the VEGF and CD105 immunoexpression in 24 cervical squamous cell carcinomas and CIN associated lesions with different degrees. For both lesions, MVD values were higher in patients who had associated risk factors. VEGF and MVD expression increased in both categories for high-grade lesions, respectively CIN III lesions compared with CIN I/II and poorly differentiated carcinomas compared with well-differentiated ones. Also, there was a statistically significant association between VEGF and MVD in poorly differentiated carcinoma and CIN III. The study indicated that analyzed markers were specific for both early and advanced stages of cervical angiogenesis. Maximum values of VEGF and MVD in CIN III designate this lesion as critical to the progression of neoplasia.

Corresponding author: Cristiana Simionescu, Professor, MD, PhD; e-mail: csimionescu2004@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

C. K. Kamal, Cristiana Eugenia Simionescu, Cl. Margaritescu, A. Stepan

Ovarian cancer is the fourth cause of death by cancer among women and the first mortality cause in gynecological neoplasia. Our goal was to evaluate p53 and Ki67 immunoexpression and also the correlations with tumor stage and type. The study included 45 primary ovarian malignant mucinous tumors, diagnosed in patients in the IV and VI decade. From the standpoint of histopathology, there were 28 cases of borderline mucinous tumors and 17 mucinous carcinomas, predominantly stage I of the disease. The immunostaining for Ki67 was positive in all the cases, the highest levels being recorded in mucinous carcinomas (22.2% medium index) compared to the borderline tumors (9.5% medium index). Opposed to Ki67, the immunoreaction for p53 was present in 37.7% of all the tumors, predominantly in mucinous carcinomas where the stain has high values (52.3% medium index) in contrast with borderline lesions (15.5% medium index). The study indicated significant differences in p53 and Ki67 immunostain in relation to the tumor stage and histological type, there being a direct correlation of the expression of both proteins, in the studied tumors. P53 and Ki67 are useful markers for evaluating aggressive tumoral behavior and differentiating between mucinous carcinomas and borderline mucinous tumors.

Corresponding author: Cristiana Simionescu, Professor, MD, PhD; e-mail: csimionescu2004@yahoo.com

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