The immunohistochemistry aspects in two cases of neurofibromatosis-associated abdominal tumors

Vol. 53 No. 2, 2012

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Mara Carsote, S. Paun, M. C. Neamtu, Elena Taina Avramescu, Cristina Iosif, Dana Terzea, S. Constantinoiu, Ruxandra Danciulescu Miulescu, Oana Maria Neamtu, Catalina Poiana

Type 1 neurofibromatosis associates various abdominal tumors as gastrointestinal stromal tumors, duodenal or pancreatic carcinoid, and adrenal tumors like pheochromocytoma. We present the immunohistochemistry report in two cases with different profile regarding the evolution. One case is a 7th decade women diagnosed with unilateral pheochromocytoma and GISTs, with a good prognosis after surgery. The other case is a 41-year-old male diagnosed with duodenal metastatic somatostatinoma after an intestinal occlusive syndrome and later the hormonal profile leaded to the diagnosis of pheochromocytoma. The patient had a fulminate evolution within six months from diagnosis.

Corresponding author: Marius Cristian Neamtu, MD; e-mail: drcristianneamtu@yahoo.com

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