Pathological characteristics and clinical specifications in gastroenteropancreatic neuroendocrine tumors: a study of 68 cases

Vol. 53 No. 2, 2012


Elena Stoica-Mustafa, C. Pechianu, Andreea Iorgescu, Monica Hortopan, Simona Olimpia Dima, V. Tomulescu, T. Dumitrascu, C. Ungureanu, D. Andronesi, I. Popescu, V. Herlea

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a group of tumors, having their origin in cells of diffuse endocrine system, with particular clinical course, diagnosis and treatment. Patients and Methods: In our study, were included 68 patients with neuroendocrine digestive tumors admitted, diagnosed and treated in Fundeni Clinical Institute, Bucharest, in the last ten years - 2000-2010 (retrospective study). Results: Thirty-three (49%) patients were males, 35 (51%) females, and the main age was 58.9 years. In 62 (90.3%) cases was possible to find the primary tumor. The examined tumors had different localizations: pancreas - 32 (47.04%) cases (head - 17 (24.99%) cases, and body and tail - 15 (22.05%) cases), stomach - 7 (10.29%) cases, small intestine - 7 (10.29%) cases, 6 (8.82%) cases - unknown primary site (diagnosis was established on metastases), right colon - 6 (8.82%) cases, liver - 6 (8.82%) cases, rectum - 2 (2.94%) cases, and retroperitoneum - 2 (2.94%) cases. Microscopic examination revealed 59 (86.8%) malignant tumors and 9 (13.2%) benign tumors. Using WHO 2000 Classification, 28 cases of malignant tumors were well-differentiated neuroendocrine carcinomas, and 31 cases were poor differentiated neuroendocrine carcinomas. From malignant cases, 25 (42.3%) have distant metastases and 15 (25.9%) lymph node metastases. Conclusions: Cases of gastroenteropancreatic neuroendocrine tumors included in our study had clinical and histopathological features in correspondence with data from literature - slight predominance in women, predominance in 5th and 6th decades of life, the most frequent localizations were at pancreatic level - both head and body and tail, but the rarest were in colon and retroperitoneum. Most of the cases studied, were malignant tumors, from these more than a half were poor differentiated, and a quarter of them having lymph node or distant metastases.

Corresponding author: Vlad Herlea, MD, PhD; e-mail:

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