Nanostructural features of diabetic podocytopathy

Vol. 53 No. 1, 2012

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

E. Mandache, M. Penescu

The earliest glomerular lesion during the diabetic nephropathy is considered by many authors to be the so-called podocytopathy. Microalbuminuria is an early clinical marker of diabetic nephropathy that results from damages of the glomerular filtration barrier at the level of the highly differentiated podocytes. Thus, the diabetic podocytopathy includes cellular hypertrophy, foot process effacement, detachment from glomerular basement membrane (GBM), and apoptosis. The present paper is reviewing all these features and some additional ultrastructural transformations concerning the podocytes involved in the diabetic kidney disease.

Corresponding author: Eugen Mandache MD, PhD, e-mail: mandache.eugen@yahoo.com

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