The involvement of TGF-beta1 and CTGF in regional gingival overgrowth
Vol. 53 No. 1, 2012
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Elena Annabel Nitulescu, Monica Mihaela Craitoiu, Monica Ileana Banita, Emma Draghici, Stefania Craitoiu
Gingival overgrowth is a multifactorial and invalidating condition. Our research is about gingival overgrowth caused by gingival plaque, its purpose being the evaluation of the presence of gingivitis and/or parodontitis in patients with gingival growth and the extent in which there is a connection between gingival overgrowth and the inflammatory process that can contribute to an exceedingly stimulation of the overgrowth. Immunohistological study was conducted on human material - gingival mucosa that came from patients with ages between 20-65 years, divided into three groups: group I - control group, group II - patients with gingivitis, group III - patients with local or general periodontitis. The intensity of immunohistochemical staining of TGF-beta1 and CTGF varies from one group to another, and also depends on the area of gingival mucosa that was observed. TGF-beta1 has a crucial role in periodontal disease fibrogenesis by intensifying the action of CTGF.
Corresponding author: Monica Mihaela Craitoiu, Assistant, MD, e-mail: mcraitoiu@yahoo.com
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