Hyperplastic polyps and serrated adenomas: precancerous lesions with mixed immunophenotype
Vol. 52 No. 3 Suppl., 2011
This supplement was not sponsored by Outside Organizations.
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Zsuzsanna Pap, Z. Pavai, L. Denes, Klara Brinzaniuc, I. Jung
Our immunohistochemical study wants to be a contribution to clarifying the adenoma-carcinoma sequence and serrated pathway of colorectal carcinogenesis. Thus, we performed immunohistochemical analysis of hyperplastic polyps (HP), serrated adenomas (SA), and classical adenomas (tubular adenomas - TA and tubulovillous adenomas - TVA) and carcinomas developed from adenomas (CA) using expression of p53, Ki-67, c-myc, APC, MSH2 and Ets-1 proteins. Because of correlation of the expression of these proteins, we propose several immunophenotypes, which show modifications along the known carcinogenetic mechanisms. Along the adenoma-carcinoma sequence we noted an increase in the expression of p53, Ki-67, c-myc and Ets-1, and a decrease in APC expression. The majority of TAs and TVAs are characterized by p53+/Ki-67+, p53+/c-myc+, p53+/APC+, and Ets-/p53+, Ets-/Ki-67+ immunophenotypes. The majority of HPs and SAs are Ets-/p53-, Ets-/Ki-67+, Ets-/c-myc+, APC+/MSH2-. In approximately 1/3 of the hyperplastic polyps and serrated adenomas, we noted that the decrease in expression of MSH2 is associated with an increase in the expression of p53, c-myc, Ki-67, and Ets-1. Thus, we can conclude that a group of hyperplastic polyps and serrated adenomas display similar immunohistochemical characteristics to tubular and tubulovillous adenomas, which delineates a group of precancerous lesions that can develop via mixed carcinogenic pathways.
Corresponding author: Zsuzsanna Pap, University Assistant, e-mail: papzsuzsa@yahoo.com
Download PDF Hyperplastic polyps and serrated adenomas: precancerous lesions with mixed immunophenotype PDFROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Emoke Pall, I. Groza, M. Cenariu, Olga Soritau, Elen Gocza, C. Tomuleasa
Embryonic stem cells have the ability to remain undifferentiated and proliferate in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. The aim of the present study was to establish mouse ES lines from blastocyst stage embryos obtained after CD1/EGFP mice superovulation. We isolated, cultured and determined the characteristics of mouse embryonic stem cells in early passages, which were first described by Evans M and Kaufman M. Therefore, we evaluated the morphological criteria for the approval of ES cells in early expansion stage. Two cell lines were isolated (CDE1 and CDE2) and analyzed. They showed similar characteristics to those reported earlier for blastocyst-derived ES cell lines.
Corresponding author: Emoke Pall, DVM, PhD student, e-mail: pallemoke@gmail.com
Download PDF Establishment of an embryonic stem cell line from blastocyst stage mouse embryos PDF
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