Endometrial carcinomas: correlation between ER, PR, Ki67 status and histopathological prognostic parameters

Vol. 52 No. 2, 2011

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Sidonia Catalina Stoian, Cristiana Simionescu, Cl. Margaritescu, A. Stepan, M. Nurciu

We present a retrospective histopathological study that included a total of 22 endometrial carcinomas, from patients that were operated in the Obstetrics and Gynecology Clinics of the Emergency County Hospital of Craiova. This current study investigates these cases in order to assess the prognostic value of the correlations between the expression of estrogen and progesterone receptors, Ki67 expression and the histological stage, tumor stage, the degree of myometrial and vascular invasion. The study showed that estrogen and progesterone positive receptors correlate significantly with early stage and well differentiated tumors. The invasion of more than half the thickness of the myometrium and the vascular invasion were associated with decreased expression of the analyzed receptors and an increased proliferation index.

Corresponding author: Sidonia Catalina Stoian, MD, PhD candidate, e-mail: sidocatalina@yahoo.com

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