Neoangiogenesis in cervical cancer: focus on CD34 assessment

Vol. 51 No. 2, 2010

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Codrina Ancuta, E. Ancuta, Fl. Zugun-Eloae, E. Carasevici

Despite recent advances in understanding the immune mechanisms of cervical cancer (CC), relapse remains still an actual issue and recognition of new predictive biomarkers is essential. Aim: The purpose of this retrospective study was to investigate neo-angiogenesis in CC and its possible utility as prognostic biomarker. Material and Methods: Paraffin-embedded tissue samples from 61 consecutive women with CC were immunostained for CD34 and E-cadherin. Statistical analysis was performed in SPSS-12 software, p<0.05. Results: Statistically significant differences between CD34 distribution among three interest tumor regions: micro-vessels density increase from central to peripheral area (chi-square, p<0.05); statistically significant correlation between CD34 expression, particularly in stromal and peripheral sites, E-cadherin (Spearman r1=-0.321) and lymphatic invasion (Spearman r2=0.455) (p<0.05) were reported. Overall five-year survival is clearly dependent on level and distribution of tumor angiogenesis among defined area of interest as suggested by Kaplan-Meier analysis. Conclusions: Angiogenesis is essential for guiding CC evolution and prognosis, particularly in squamous invasive types.

Corresponding author: Codrina Ancuta, Lecturer, MD, PhD, e-mail: alexia02ro@yahoo.com

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