Bcl-2 expression in Hodgkin's lymphoma progression

Vol. 49 No. 3, 2008

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Corina Flangea, Elena Potencz, Rodica Mihăescu, S. Gîju, A. Anghel

Introduction: Hodgkin's lymphoma study by immunohistochemical expression of Bcl-2 in Hodgkin and Reed-Sternberg cells can precise these cases evolutive way. Material and methods: Sixty-three cases of classical Hodgkin's disease, hospitalized into the Hematology Department of the No. 1 Emergency County Hospital Timisoara, were studied. Histopathological diagnostic was performed using common staining methods, and for revealing the tumoral developments immunohistochemical staining was performed Bcl-2. Results and discussion: In our study, the results were noticed a direct relation between the rise of tumoral proliferation index expressions of Bcl-2 and progression of the disease (p<=0.001). For I and II stages Bcl-2 expression does not overcome (-/+) category while the III and IV stages, all the cases are situated in (+/-) and (+) categories. No connection we can be noticed between the histological type and Bcl-2 expression although the classic Hodgkin's lymphoma with lymphocyte depletion is considered the most aggressive histological type (p<=1). In our study, we found this correlation very important because the main cause of relapses is inadequate staging. In some cases, this staging is difficult; some little lymph nodes could be overlooked because they can be placed in less accessible areas and cannot be evidenced by the most imagistic methods. Conclusions: All the cases were Bcl-2 expression higher than (+/-) and are staged as I and II stages should be reinvestigated and restaged. This immunohistochemical reaction, although less used in Romania, is very accurate. That is very important because the therapeutically attitude is different in advances stages compared to earlier stages.

Corresponding author: Corina Flangea, MD, PhD, e-mail: flangeacorina@yahoo.com

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