The chick embryo chorioallantoic membrane in the study of tumor angiogenesis

Vol. 49 No. 2, 2008

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

D. Ribatti

The chick embryo chorioallantoic membrane (CAM) is commonly used as an experimental in vivo assay to study both angiogenesis and antiangiogenesis in response to tissues, cells or soluble factors. This article summarizes literature data about the use of the CAM in the study of tumor angiogenesis and particularly our experimental data concerning the study of angiogenesis in multiple myeloma and in neuroblastoma.

Corresponding author: Domenico Ribatti, MD, PhD, e-mail: ribatti@anatomia.uniba.it

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