Apoptosis in cutaneous melanomas

Vol. 48 No. 4, 2007

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Mariana Costache, Olga Simionescu, Maria Sajin, Alina Chefani, Ana Maria Ene, Ana Maria Teodorov, Elena Ionica

Cutaneous melanomas has become one of the most discussed and studied tumor because its particular immunologic development but also its increasing rate worldwide in the last decades. Even thought many patients are diagnosed at an early stage, the death rate continues to rise due to the increasing incidence of more advanced lesions. The aim of this study is to detect apoptosis in 30 cases of cutaneous melanomas using the in situ end-labeling technique (TUNEL) who quantify apoptotic cell death at single cell level and tissues.

Corresponding author: Mariana Costache, MD, PhD, e-mail: m_costache_dermatopat@yahoo.com, angelap@vbabes.ro

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