Macro- and microanatomic factors involved in the flat bones morphogenesis from the craniofacial system

Vol. 48 No. 3, 2007


Mihaela Iustina Meşină-Botoran, C. Meşină, G. S. Drăgoi, L. Mogoantă, R. L. Neamțu

The authors present a study both upon eight crania of dead born fetuses having the vertex-coccis distance between 25-29 cm and a human embryocephalic extremity of 18 cm. The crania were examined in the lateral, vertical, frontal, occipital, basal norms. Sagittal sections were performed upon the embryo, and then those sections were microscopically examined after HE staining. We concluded that the cranial arch bones morphogenesis and the facial complex is a long-time development process, which initially started during the early embryogenesis, and it is completed as an adult. Determining factors of the flat bones osteogenesis are the following: vascular, muscle, extracell (mesenchyma) and neuronal factors (rhombencephalon presence).

Corresponding author: Mihaela Iustina Meşină-Botoran, MD, PhD, e-mail:

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