Predictive parameters for advanced neoplastic adenomas and colorectal cancer in patients with colonic polyps - a study in a tertiary medical centre in the South-West region of Romania

Vol. 47 No. 3, 2006

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Sevastița Iordache, A. Săftoiu, T. Ciurea, Claudia Valentina Georgescu, Mirela Ghiluşi

Although many papers had described the role of colorectal adenomas and the risk for colon cancer, there is a lack of data about epidemiological factors, the histological type, the pit-pattern and type of polyps in Romania. In polypoid adenomas the risk of malignant transformation is well known, and is increasing over time with size and villous architecture. In this paper, we evaluate the predictive parameters that allowed us to establish a correlation between the macroscopical aspect and histological architecture of adenomas in our geographical area (South-West region of Romania). Two predictive parameters of cancer characterize early neoplastic lesions: their size and their surface elevation (elevated, flat or depressed). The morphology of adenomas and multiplicity of polyps also have a prognostic value. In our study, the main localization of polyps was in the left colon, while the main histological type was tubulo-villous adenomas. We consider that the significant parameters for dysplasia and malignant lesions are the size of lesions, multiplicity of polyps and villous architecture.

Corresponding author: Sevastița Iordache, MD, PhD candidate, e-mail: sevastita@gmail.com

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