P53 protein and bcl-2 expression in glioblastomas. Pathological correlations in a comprehensive series

Vol. 46 No. 4, 2005

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Carmen Ardeleanu, M. Ceausu, Georgeta Butur, Zenaida Florea Gramada, L. Danaila, Fl. Halalau, D. Arsene

P53 and bcl-2 are two well-known antiapoptotic factors associated with gliomas, and mostly astrocytic tumors. In the present study, we assessed, by immunohistochemistry, the expression of these two factors in a series of 50 glioblastomas. The correlations between their expression and several tumor-related factors (age, location, recurrence, proliferating potential) were investigated. Our results suggest that a valuable correlation between these factors cannot be found. This is in discrepancy with some literature data, which emphasize strong relations of p53 and bcl-2 in oncogenesis spreading or final prognosis. Further studies are needed with unique standard procedures for these evaluations.

Corresponding author: Carmen Ardeleanu, MD, PhD, e-mail: carmena@vbabes.ro

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