Tumoral stroma of salivary pleomorphic adenoma - histopathological, histochemical and immunohistochemical study
Vol. 46 No. 3, 2005
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Cl. Margaritescu, M. Raica, Cristiana Simionescu, L. Mogoanta, M. Surpateanu, F. Jaubert, Fl. Bogdan
The aims of our paper were to establish the main histopathological, histochemical and immunohistochemical aspects of tumoral stroma from salivary pleomorphic adenomas. For this purpose, we investigated 103 cases by the classical histopathological technique with paraffin embedding and staining with Hematoxylin-Eosin (HE), Hematoxylin-Eosin-Safranin (HES), trichromic Masson, trichromic Goldner Szeckelly, orcein and Periodic Acid Schiff-Blue Alcian (PAS-AA). Immunohistochemically, they were investigated for AE1-AE3, MNF116, CK8, EMA, vimentin, alpha-actin calponin, S-100, GFAP, collagen IV, and PCNA. The results of our study suggest the key role of neoplastic myoepithelial cell in the achievement of diverse morphological aspects of stroma in such neoplasms.
Corresponding author: Claudiu Margaritescu, MD, PhD, e-mail: mclaudiu@umfcv.ro, c_margaritescu@hotmail.com
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