Histiocytic sarcoma associated with Hodgkin's disease
Vol. 46 No. 3, 2005
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Elena Doina Murarescu, Rodica Lighezan, D. Negru, Irina Rodica Chiselita, P. Plamadeala, Maria Sultana Mihailovici
Histiocytic sarcoma is a rare malignant neoplasm. It is well-known the association of Langerhans' cell histiocytosis with Hodgkin's disease but only few cases of histiocytic sarcoma associated with Hodgkin's disease was reported. We present the case of 20-years-old female patient with Hodgkin's disease with a sternal tumor mass, which was diagnosed as histiocytic sarcoma. The diagnostic was established immunohistochemically, using a large battery of antibodies (S-100, CD 68, CD 34, CD 15, CD 30, Vim, NFAP) and by electron microscopy which revealed the lack of the Birbeck granules in the malignant proliferated histiocytes.
Corresponding author: Elena Doina Murarescu, MD, PhD, e-mail: doinamurarescu@yahoo.com
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