A rare case of glioblastoma multiforme

Vol. 46 No. 2, 2005

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

I. Radu, A. Nicola, Daniela Micu, D. Minea

A male, 39 years, enters rapidly in coma, is admitted in the Neurological Hospital Brasov and deceases after 4 hrs. in hospital. At necropsy, macroscopic appearances of the cut surface showing unique tumor mass in all brain from frontal lobe to cerebellum, with extensive cortical invasion. The tumor has a variable coloration, a yellowish central necrosis and cystis containing turbid fluid. Histopathological aspect is extremely variable with regional heterogeneity: striking cellular pleomorphism with a lack of cell processes, anaplastic glial cells, and some multinucleated giant cells, large necrotic areas with pseudopalisading of surrounding tumor cells and microvascular proliferation, as glomeruloid tufts.

Corresponding author: Ioan Radu, MD, PhD, e-mail: raduic@k.ro

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